Rudyanto, Marcellino and Hartanti, Lanny (2008) Synthesis Of Some Cinnamic Acid Derivatives: Effect Of Groups Attached On Aromatic Ring To The Reactivity Of Benzaldehyde. Indonesian Journal of Chemistry, 8 (2). pp. 226-230. ISSN 1411-9420
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Abstract
Synthesis of cinnamic acid and its six derivatives has been done by employing Knoevenagel reaction. Benzaldehyde, 4-butylbenzaldehyde, 4-t-butylbenzaldehyde, 4-butoxybenzaldehyde, 4-phenylbenzaldehyde, 5-bromo-2,4-dimethoxybenzaldehyde, and 5-bromo-2,3-dimethoxybenzaldehyde were reacted with malonic acid in pyridine – piperidine to give cinnamic acid (85,3%), 4-butylcinnamic acid (69,3%), 4-t-butylcinnamic acid (77,7%), 4-butoxycinnamic acid (64,5%), 4-phenylcinnamic acid (65,5%), 5-bromo-2,4-dimethoxycinnamic acid (53,2%) and 5-bromo-2,4-dimethoxycinnamic acid (57,2%), respectively. It was disclosed that 4-alkyl, 4-alkoxy, 4-aryl, dan 2-alkoxy groups decrease the reactivity of carbonyl carbon of benzaldehyde.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cinnamic acid, cinnamic acid derivatives, Knoevenagel reaction. |
| Subjects: | Pharmacy |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 06 Jun 2024 09:19 |
| Last Modified: | 06 Jun 2024 09:19 |
| URI: | http://repository.ukwms.ac.id/id/eprint/39721 |
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