Inhibitory Potential Of Some Synthetic Cinnamic Acid Derivatives Towards Tyrosinase Enzyme

Hartanti, Lanny and Setiawan, Henry Kurnia (2009) Inhibitory Potential Of Some Synthetic Cinnamic Acid Derivatives Towards Tyrosinase Enzyme. Indonesian Journal of Chemistry, 9 (1). pp. 158-168. ISSN 1411-9420

	Text (Inhibitory Potential Of Some Synthetic Cinnamic Acid Derivatives Towards Tyrosinase Enzyme) 5-Inhibitory_potential_of_some_.pdf Download (1MB)
	Text (Inhibitory Potential Of Some Synthetic Cinnamic Acid Derivatives Towards Tyrosinase Enzyme) 5-Inhibitory_potential_of_some_Hasil Cek Similariy.pdf Download (2MB)

Official URL: https://jurnal.ugm.ac.id/ijc/about/editorialPolici...

Abstract

Cinnamic acid is one of known tyrosinase inhibitors. This study investigated the inhibition of tyrosinase activity of some cinnamic acid derivatives, i.e. 4-buthoxy-cinnamic acid, 4-n-butylcinnamic acid and 4-phenylcinnamic acid. Each inhibitor used in this research had the same type of inhibition towards enzymatic activity, i.e. mixed type inhibition of competitive and non competitive type. The potential sequence of tyrosinase inhibition based on the ratio of its IC50 compared to cinnamic acid, from the lowest to the highest were 4-buthoxycinnamic acid, 4-phenylcinnamic acid and 4-n-butylcinnamic acid. Based on the obtained results of this research, it was disclosed that n-butyl substituent on para position did not increase the inhibition effect of cinnamic acid towards tyrosinase enzymatic reaction. But in the other hand, buthoxy and phenyl substituent on para position could increase the inhibition effect of cinnamic acid towards tyrosinase enzymatic reaction because buthoxy substituent increased the similarity of its structure with the substrate of enzymatic reaction while phenyl susbtituent blocked the substrate-enzyme reaction.

Item Type:	Article
Uncontrolled Keywords:	tyrosinase; L-DOPA; inhibition kinetics; IC50, cinnamic acid
Subjects:	Pharmacy
Divisions:	Journal Publication
Depositing User:	F.X. Hadi
Date Deposited:	07 Jun 2024 04:36
Last Modified:	07 Jun 2024 04:36
URI:	http://repository.ukwms.ac.id/id/eprint/39725

Actions (login required)

View Item