pH-responsive hollow core zeolitic-imidazolate framework-8 as an effective drug carrier of 5-fluorouracil

Anggraini, S.A., Prasetija, Kevin Adiputra, Yuliana, Maria, Wijaya, C.J., Bundjaja, Vania, Angkawijaya, Artik Elisa, Jiang, Yi-Fan, Putro, Jindrayani Nyoo, Hartono, S.B., Ayucitra, Aning, Santoso, Shella Permatasari, Ismadji, Suryadi and Soetaredjo, Felycia Edi (2023) pH-responsive hollow core zeolitic-imidazolate framework-8 as an effective drug carrier of 5-fluorouracil. pH-responsive hollow core zeolitic-imidazolate framework-8 as an effective drug carrier of 5-fluorouracil, 27. p. 101277. ISSN 2468-5194

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Abstract

To enhance the porosity and accessibility, a novel drug carrier, the hollow core zeolitic-imidazolateramework-8 (HZIF-8), is designed using polystyrene as a hard template to sequentially load and release 5-fluorouracil (FU). HZIF-8 is signified by a large surface area and pore volume, reaching 1727.1 m2/g and 0.99 cm3/g, respectively. The obtained HZIF-8 exhibits rhombic dodecahedron morphology with a uniform particle size of 450 nm. The integrated hollow core is observed at ca. 180 nm. Evaluation of the FU encapsulation behavior in HZIF-8 nanospheres is demonstrated via the adsorption kinetics, isotherm, and thermodynamic studies. The maximum FU uptake is monitored at 40 �C with the pacity of 161.9 mg/g. This study suggests that the FU uptake follows the pseudo-second-order law and multilayer mechanism. The governing mechanism is chemical binding in its first layer and physical interaction in the upper layers. The release study of FU from FU-loaded HZIF-8 shows that the cumulative release at pH 5.5 (92.03%) is four times higher than that at pH 7.4 (23.31%), indicating a stimulus-responsive release mechanism where pH is required as an internal stimulus factor

Item Type: Article
Uncontrolled Keywords: Hollow ZIF-8 ug delivery system ZIF-8 Cancer Stimuli-responsive
Subjects: Engineering > Chemical Engineering
Divisions: Journal Publication
Depositing User: F.X. Hadi
Date Deposited: 17 Nov 2023 05:31
Last Modified: 02 Feb 2024 05:40
URI: http://repository.ukwms.ac.id/id/eprint/37377

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