Preparation and characterization of formic acid modulated HKUST-1 for doripenem drug delivery

Denesa, Erwhyanta Monorizho and Yohanes, Steven (2022) Preparation and characterization of formic acid modulated HKUST-1 for doripenem drug delivery. Working Paper (Laporan Penelitian Laboratorium (FT-Kimia)). Faculty of Engineering, Surabaya. (Submitted)

	Text (ABSTRAK) ABSTRAK.pdf Download (2MB)
	Text (BAB 1) BAB 1.pdf Download (37kB)
	Text (BAB 2) BAB 2.pdf Restricted to Registered users only Download (185kB) | Request a copy
	Text (BAB 3) BAB 3.pdf Restricted to Registered users only Download (114kB) | Request a copy
	Text (BAB 4) BAB 4.pdf Restricted to Registered users only Download (826kB) | Request a copy
	Text (BAB 5) BAB 5.pdf Download (125kB)
	Text (LAMPIRAN) LAMPIRAN.pdf Restricted to Registered users only Download (551kB) | Request a copy

Abstract

Doripenem is an antibiotic with high effectiveness in treating infections. However, the dose of doripenem is only partially used, so the rest will be wasted through the secretory system. Therefore, a drug carrier is needed to control the release of doripenem efficiently. Hong Kong University of Science and Technology-1, or HKUST-1, is a metal organic framework used as a drug carrier of doripenem. Formic acid is a carboxylic acid other than acetic acid, which is used in synthesizing HKUST-1 as a modulator. This study aimed to examine the effect of modulators on the synthesis of HKUST-1 as the doripenem drug carrier. The addition of a modulator gave the different yields and particle sizes of HKUST-1. The results of this study indicate that the modulated HKUST-1 used has a sips isotherm model. For the Qmax value of HKUST-1 of 413.66 mg/g, acetic acid fragmented HKUST-1 of 445.36 mg/g, 1 mL of formic acid-fragmented HKUST-1 of 486.65 mg/g and 5 mL of formic acid-fragmented HKUST-1 298.28 mg/g. In drug loading and drug release application, the modulator positively affects the adsorption process but not in the drug release process.

Item Type:	Monograph (Working Paper (Laporan Penelitian Laboratorium (FT-Kimia)))
Department:	S1 - Teknik Kimia
Contributors:	Contribution Contributors NIDN / NIDK Email Thesis advisor Ismadji, Suryadi NIDN0721126901 suryadiismadji@yahoo.com Thesis advisor Lie, Jenni NIDN0728119501 lie.jenni07@gmail.com
Subjects:	Engineering Engineering > Chemical Engineering
Divisions:	Faculty of Engineering > Chemical Engineering Study Program
Depositing User:	Erwhyanta Monorizho Denesa
Date Deposited:	03 Jul 2023 06:43
Last Modified:	03 Jul 2023 06:43
URI:	http://repository.ukwms.ac.id/id/eprint/35312

Actions (login required)

View Item