Phytochemicals of Gandarusa (Justicia gendarussa) and Its Preparations

Ratih, Gusti Ayu Made, Imawati, Maria Fatmadewi, Nugroho, Rendra Rizki, Purwanti, Diah Intan, Wongso, Suwidji, Prajogo, Bambang and Indrayanto, Gunawan (2019) Phytochemicals of Gandarusa (Justicia gendarussa) and Its Preparations. Phytochemicals of Gandarusa (Justicia gendarussa) and Its Preparations, 14 (6). pp. 1-5. ISSN pISSN: 15559475, eISSN: 1934578X, Jurnal Internasional bereputasi, SJR(2019): 0.199, Q4, H-Index: 50

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Abstract

Thirty-five metabolites of Justicia gendarussa (JG) leaves and its preparations were identified using LC-HR-MS/MS. Although alkaloids were detected in the leaves they were not identified in JG preparations using Smart Formula 3D software. This showed that an acidified extraction process used at the first stage of the purification procedure is able to remove the toxic alkaloids from the crude drug. The LC-MS/MS analyses showed that the main components of JG preparations were fatty acids and apigenin glycosides; it seemed that the fatty acids can be used for enhancing the dissolution of the polar glycosides. T-test calculation using Profile Analysis software showed that the acidified crude drugs, extract, granules of JG, and gendarussa capsules showed very similar LC-MS/MS profiles, which means that the biochemical components of JG are relatively stable during processing. Due to the lack of quality markers for these JG preparations, the application of metabolite profiling is recommended as the QC tool for commercial production by the pharmaceutical industry.

Item Type:	Article
Additional Information:	Jurnal Internasional bereputasi, SJR(2019): 0.199, Q4, H-Index: 50
Uncontrolled Keywords:	alkaloids, apigenin glycosides, extract of gendarussa, gendarussa capsules, Justicia gendarussa , LC MS/MS profiling
Subjects:	Office Administration
Divisions:	Journal Publication
Depositing User:	F.X. Hadi
Date Deposited:	16 Nov 2022 09:05
Last Modified:	16 Nov 2022 09:05
URI:	http://repository.ukwms.ac.id/id/eprint/32425

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