An iron–carboxylate-based metal–organic framework for Furosemide loading and release

Devi, Yanita, Ang, Ignatius, Soetaredjo, Felycia Edi, Santoso, Shella Permatasari, Irawaty, Wenny, Yuliana, Maria, Angkawijaya, Artik Elisa, Hartono, Sandy Budi, Nguyen Tran, Phuong Lan, Ismadji, Suryadi and Ju, Yi-Hsu (2020) An iron–carboxylate-based metal–organic framework for Furosemide loading and release. An iron–carboxylate-based metal–organic framework for Furosemide loading and release, 55 (06). pp. 13785-13798. ISSN 00222461, 15734803, Jurnal Internasional Bereputasi SJR(2020): 0.81, Q1, H-Index: 177

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Abstract

An iron–carboxylate-based metal–organic framework, Fe-MIL100, has been synthesized using acid-free solvent at room temperature. Fe-MIL100 was prepared by combining Fe/H3BTC/NaOH/H2O (H3BTC = trimesic acid) at a molar ratio of 1.5:1.0:x:880, where x is the varied NaOH concentration at 1.5, 3.0, and 5.0 M. The effect of NaOH molar oncentration on the formation of Fe-MIL100 was studied. Characterizations of the Fe-MIL100 were carried out using powder X-ray diffraction (XRD), scanning electron microscopy (SEM), nitrogen (N2) adsorption–desorption, and thermogravimetry analysis (TGA). The obtained Fe-MIL100, with x NaOH of 3.0 M, has an octahedral crystal shape (a = 73.41 A ° ), crystal size ranging from 100 to 400 nm, BET surface area of 1,446.4 m2/g, a pore volume of 0.829 cm3/g, and thermal degradation temperature of 358 �C. The potential of Fe-MIL100, a drug carrier device, was tested against Furosemide (a loop diuretic). As studied using the Langmuir adsorption isotherm model, 392.4 mg of Furosemide can be loaded per g of Fe-MIL100. The kinetic release of Furosemide was examined at 2 different biological pH of 5.8 and 7.4. The release profile of Furosemide was recorded within 24 h; it was found that the release profile follows the pseudo-first-order kinetics at pH 5.8 with a percent cumulative release of 41.56% and Korsmeyer–Peppas model at pH 7.4 with a percent cumulative release of 68.46%. The electrostatic repulsion drove the release of Furosemide from Fe-MIL100 due to the same negative charge of the compounds. Fe-MIL 100 at low concentration (\30 lg/mL) shows good biocompatibility toward the 7F2 normal cell lines.

Item Type: Article
Additional Information: Jurnal Internasional Bereputasi SJR(2020): 0.81, Q1, H-Index: 177
Subjects: Engineering > Chemical Engineering
Divisions: Journal Publication
Depositing User: F.X. Hadi
Date Deposited: 11 Jul 2022 06:53
Last Modified: 02 Dec 2022 08:14
URI: http://repository.ukwms.ac.id/id/eprint/31313

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