Wijaya, Sumi, Jin, Khoo Teng, Nee, Ting Kang and Wiart, Christophe (2012) In Vitro 5-LOX Inhibitory and Antioxidant Activities of Extracts and Compounds from the Aerial Parts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. Journal of Complementary and Integrative Medicine, 9 (1). pp. 1-14. ISSN 1553-3840, Journal Internasional Bereputasi Q2, SJR 0.206
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Abstract
The aim of this study was to investigate the antioxidant and anti-inflammatory potentials of crude extracts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. and its isolated compounds. Separation and structure elucidation of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. were conducted using chromatographic and spectroscopic method. The antioxidant activities of the extracts in this study were determined by the ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and β-carotene bleaching assays meanwhile the antiinflammatory activity was evaluated using the 5-lipoxygenase assay. Seven known compounds quercetin 3-O-glucoside (1), naringenin 7-O-glucoside (2), seneciphylline-O-glucoside (3), chrysoeriol (4), retrorsine (5), adonifiline (6) and 5,4′-di-O-methyl alpinumisoflavone (7) were isolated from ethanol extract of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. The ethanol and water extracts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. elicited potent antioxidant and anti-inflammatory properties. Amongst the isolated compounds quercetin 3-Oglucoside gave strong antioxidant activity and adonifiline strongly inhibited 5-lipoxygenase activity.
Item Type: | Article |
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Additional Information: | Journal Internasional Bereputasi, Q2, SJR 0.294 |
Uncontrolled Keywords: | Lopholaena coriifolia, flavonoids, alkaloids, antioxidant, anti-inflammatory |
Subjects: | Pharmacy |
Divisions: | Journal Publication |
Depositing User: | F.X. Hadi |
Date Deposited: | 09 Oct 2019 08:00 |
Last Modified: | 16 Aug 2021 03:01 |
URI: | http://repository.ukwms.ac.id/id/eprint/20126 |
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