Twisted-chiral mesoporous silica from coconut husk waste designed for high-performance drug uptake and sustained release

Retnoningtyas, Ery Susiany (2024) Twisted-chiral mesoporous silica from coconut husk waste designed for high-performance drug uptake and sustained release. Microporous and Mesoporous Materials, 367. pp. 1-9. ISSN 1387-1811

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Abstract

With an annual production of 2.81 million tons, the coconut husk is an essential source of silica. Various advantages of silica as a drug carrier make it one of the most developed materials in drug delivery applications. To improve the drug delivery performance of a material, twisted chirality is also classified as a critical factor because the pharmacological activity depends on the interaction of the drug with the drug carrier material in the target area. In this study, the coconut husk-based mesoporous silica (MS) can be synthesized through a calcination and sol-gel method. With the help of anionic surfactant, MS is successfully modified to have a twistedchiral structure (CMS). CMS is characterized by twisted rod-like morphology at a size of 1–2 μm, with a helical arrangement (mixed with the beta-sheet and random coil conformations). CMS’s surface area and pore volume are obtained at 288.3 m2/g and 0.614 cm3/g, with an average pore size of 7.63 nm. The maximum adsorption of tetracycline (506.5 mg/g) is reached at pH = 4, with the initial concentration of tetracycline at 400 mg/g, temperature of 323 K, and adsorption time of 600 min. The loading of tetracycline follows the pseudo-firstorder model with a monolayer mechanism. The bulk migration of tetracycline from the solution into the surface of CMS is deemed the primary adsorption mechanism. The in-vitro release study of tetracycline at pH = 7.4 follows the slow-sustained release model with the cumulative release at 72.3 %, showing better release performance compared with the common MS.

Item Type:	Article
Uncontrolled Keywords:	Biomass-based silica Twisted-chiral structure Sustainable material Mesoporous material Tetracycline Drug uptake/release
Subjects:	Engineering > Chemical Engineering
Divisions:	Journal Publication
Depositing User:	F.X. Hadi
Date Deposited:	08 Oct 2024 06:32
Last Modified:	08 Oct 2024 06:32
URI:	https://repository.ukwms.ac.id/id/eprint/41030

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