Wilianto, Yufita Ratnasari and Yulistiani, . (2019) Side Effects of Antipsychotics on Schizophrenia Patients : A Literature Review. Side Effects of Antipsychotics on Schizophrenia Patients : A Literature Review, 4 (2). pp. 35-44. ISSN 2461-114X , Jurnal Nasional Trindek Sinta 4
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Abstract
Schizophrenia is a chronic mental disorder that is characterized by distracted mind, behavioral changes, including delusions and hallucinations. The incidence of schizophrenia is 1.25% of the 2.47% of the psychotic disorder population. Pharmacological therapy given to schizophrenia patient is antipsychotic agents that work on the brain neurotransmitters including dopamine, serotonin, and glutamate. Atypical antipsychotic agents are the first-line therapy for schizophrenia, whereas typical antipsychotics are used as the second line when there is no improvement in symptoms. However antipsychotics agents have frequent side effects such as weight gain and extrapyramidal symptoms. Other reported side effects are including increased prolactin level (sexual dysfunction and menstrual irregularity), cardiovascular system disturbance (hypotension and prolonged QT interval), and lipid changes (elevated triglyceride and cholesterol). Consequences of these side effects can lead to poor adherence of patients, disease progressiveness and increase of physical morbidity and mortality. This article uses 42 literatures with literature parameters used over the past ten years. The purpose of this article is to provide a concise review of schizophrenia and discusses the side effects of atypical and typical antipsychotics based on literature reviews.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Atypical Antipsychotics; Mental Disorder; Schizophrenia; Side Effects; Typical Antipsychotics. |
| Subjects: | Pharmacy |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 15 Jan 2021 03:50 |
| Last Modified: | 19 Feb 2021 04:29 |
| URI: | https://repository.ukwms.ac.id/id/eprint/24024 |
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