Simon, Meta A, Anggraeni, Erlina, Soetaredjo, Felycia Edi, Santoso, Shella Permatasari, Irawaty, Wenny, Thanh, Truong Chi, Hartono, Sandy Budi, Yuliana, Maria and Ismadji, Suryadi (2019) Hydrothermal synthesize of HF-Free MIL-100(Fe) for isoniazid-drug delivery. Hydrothermal synthesize of HF-Free MIL-100(Fe) for isoniazid-drug delivery, 9. pp. 1-11. ISSN 20452322
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Abstract
Sustainable development of drug delivery materials with good biocompatibility and controlled-release is a popular topic among researchers. In this research study, we demonstrated the potential of the metal-organic framework, that is MIL-100(Fe), as a drug delivery platform for isoniazid (INH). The MIL-100(Fe) was prepared by using the hydroluoric acid-free hydrothermal method. Several physical measurements were conducted to characterize the MIL-100(Fe), including x-ray difraction (XRD), scanning electron microscopy (SEM), nitrogen sorption, and thermal-gravimetric (TG). The synthesized MIL-100(Fe) has octahedron-shaped particles with superior properties, that is large surface area (1456.10 m2/g) and pore volume (1.25 cm3/g). The drug loading rate and capacity were determined by means of adsorption kinetic and isotherm. The studied INH@MIL-100(Fe) adsorption system kinetics follow the pseudo-irst-order model, while the isotherm system follows the Langmuir model with the maximum adsorption capacity of 128.5 mg/g at 30 °C. MIL-100(Fe) shows adequate biocompatibility, also exhibits a reasonable and controlled drug release kinetics. The results obtained show that MIL-100(Fe) can be a good choice of drug delivery platform among other available platforms.
| Item Type: | Article |
|---|---|
| Subjects: | Engineering > Chemical Engineering |
| Divisions: | Faculty of Engineering > Chemical Engineering Study Program |
| Depositing User: | Wenny Irawaty |
| Date Deposited: | 07 Feb 2020 10:04 |
| Last Modified: | 21 Jul 2020 05:49 |
| URI: | https://repository.ukwms.ac.id/id/eprint/21506 |
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