Complexes of 2,6-dihydroxybenzoic acid with divalent metal ions: Synthesis, crystal structure, spectral studies, and biological activity enhancement

Santoso, Shella Permatasari, Ismadji, Suryadi, Angkawijaya, Artik Elisa, Soetaredjo, Felycia Edi, Go, Alchris Woo and Ju, Yi Hsu (2016) Complexes of 2,6-dihydroxybenzoic acid with divalent metal ions: Synthesis, crystal structure, spectral studies, and biological activity enhancement. Journal of Molecular Liquids, 221. 617 -623. ISSN 0167–7322

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Abstract

2,6-Dihydroxybenzoic acid or γ-resorcylic acid (DHBA) is a phenolic compound which is known to have poor biological performance such as DPPH scavenging activity and microbial growth inhibition. Combining DHBA with divalent metal ion to form complex is expected to improve its biological properties. The complexes of DHBA with divalent Ni/Co were synthesized and characterized in this study. The complex structures were determined by Xray single crystal analysis and it was found that metal interacted with DHBA through H-bonds. The results on the biological properties indicate that the complexes have remarkable DPPH scavenging activities and microbial growth inhibition abilities. IC0.5 value of DPPH is 35.68 mg/L (231.51 μM), 9.21 mg/L (18.09 μM) and 25.63 mg/L(50.33 μM) for DHBA, NiDHBA and CoDHBA respectively. The microbial growth inhibitory value (%) at a sample concentration of 400 mg/L is 2.9, 6.4 and 96.1 against Escherichia coli and 4.9, 16.8, 98.2 against Staphylococcus aureus, for DHBA, NiDHBA and CoDHBA, respectively.

Item Type:	Article
Uncontrolled Keywords:	2,6-dihydroxybenzoic acid γ-resorcylic acid Metal ligand Hypspec Crystal structure
Subjects:	Engineering > Chemical Engineering
Divisions:	Faculty of Engineering > Chemical Engineering Study Program
Depositing User:	Felycia Edi Soetaredjo
Date Deposited:	17 Jul 2017 08:31
Last Modified:	14 Jun 2019 08:01
URI:	https://repository.ukwms.ac.id/id/eprint/11042

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