Nanocrystalline cellulose for potential application of drug delivery

Saputra, Stephanie Novina and Wijaya, Christian Julius (2016) Nanocrystalline cellulose for potential application of drug delivery. Working Paper (Laporan Penelitian Laboratorium (FT-Kimia)). Faculty of Engineering, Surabaya. (Unpublished)

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Abstract

Nanocrystalline cellulose (NCC) is an advanced material which can be used in many applications, such as pharmaceutical, health, food, chemical, and etc. Because of that, NCC is very potential to be developed from many kinds of raw materials. In this research, passion fruit peels waste is used as the raw material of NCC production, because this raw material contains cellulose until 26.52% wt. Besides that, the use of this raw material is to decrease the need of woods, where the big need of woods will give damages to the environment. If the need of woods is big, the forest exploitation will increase significantly. Because of that, the industrial waste likes passion fruit peels waste is needed. In this research, NCC was applied in drug delivery system, where NCC was used as the adsorbent of tetracycline antibiotic. NCC is used in this application because of its biodegradable and easy to modify characteristics. NCC can carry the tetracycline antibiotic to the target in human body, and release that drug. From this application, the efficiency and effectiveness of the drug activity will increase significantly. This research is aimed to study the NCC production from passion fruit peels waste and the adsorption isotherm, the adsorption kinetic, and the desorption kinetic of tetracycline antibiotic by NCC. From this research, the data which was obtained are the yield percentage of NCC in various variables of NCC production and the best equations for the adsorption and desorption process in its various variables. In this research, the best condition was obtained (based on highest yield of NCC, 2.86% wt.) using 52% wt. of sulphuric acid concentration at 50ºC. The materials used and obtained in this research were analysed using TGA, XRD, and SEM. This NCC was suitable as drug carrier of tetracycline antibiotic. It was proofed from the adsorption and desorption mechanism. This material can adsorbed tetracycline antibiotic as much as 251.7667 mg/g using 500 ppm as tetracycline initial concent ration in 60 minutes at 30ºC. The adsorbed tetracycline was released slowly in 12 hours, where the desorption efficiency reached 90.51%.

Item Type: Monograph (Working Paper (Laporan Penelitian Laboratorium (FT-Kimia)))
Department: ["eprint_fieldopt_department_Faculty of Engineering" not defined]
Subjects: Engineering > Chemical Engineering
Divisions: Faculty of Engineering > Chemical Engineering Study Program
Depositing User: Users 3746 not found.
Date Deposited: 17 Jan 2017 04:38
Last Modified: 17 Jan 2017 04:38
URI: http://repository.ukwms.ac.id/id/eprint/9332

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