Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation,and delivery carriers

Popat, Amirali, Hartono, Sandy Budi, Stahr, Frances, Jian, Liu, Shi, Zhang Qiao and Gao, Qing Max Lu (2011) Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation,and delivery carriers. Nanoscale, 3. pp. 2801-2818. ISSN 2040-3372

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Mesoporous silica nanoparticles (MSNs) provide a non-invasive and biocompatible delivery platform for a broad range of applications in therapeutics, pharmaceuticals and diagnosis. The creation of smart, stimuli-responsive systems that respond to subtle changes in the local cellular environment are likely to yield long term solutions to many of the current drug/gene/DNA/RNA delivery problems. In addition, MSNs have proven to be promising supports for enzyme immobilisation, enabling the enzymes to retain their activity, affording them greater potential for wide applications in biocatalysis and energy. This review provides a comprehensive summary of the advances made in the last decade and a future outlook on possible applications of MSNs as nanocontainers for storage and delivery of biomolecules. We discuss some of the important factors affecting the adsorption and release of biomolecules in MSNs and review of the cytotoxicity aspects of such nanomaterials. The review also highlights some promising work on enzyme immobilisation using mesoporous silica nanoparticles

Item Type: Article
Subjects: Engineering > Electrical Engineering
Divisions: Journal Publication
Depositing User: Sandy Budi Hartono
Date Deposited: 21 Jan 2016 02:36
Last Modified: 23 May 2017 05:25

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