Effect of oral intake of microplastic on the changes in nephron structure among male wistar rats

Palyama, Priskilla Naomi, Sincihu, Yudhiakuari and Parengkuan, Irene Lingkan (2023) Effect of oral intake of microplastic on the changes in nephron structure among male wistar rats. Effect of oral intake of microplastic on the changes in nephron structure among male wistar rats, 5 (3). pp. 162-169. ISSN 2565-1409

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Abstract

Introduction: Microplastic bioaccumulation in nephron tissue can cause high levels of nephron mitochondrial reactive oxygen species, endoplasmic stress, and inflammation-related proteins. Purpose: to observe damage to the tubules and glomeruli structures in the experimental group exposed to microplastic particles Methods: This study observed damage to experimental animals' tubular and glomerular structures due to oral intake of microplastics. 46 Wistar rats used were divided into one control (C) and five experimental groups (Xn). The experimental group was exposed to low-density polyethylene microplastic doses of 0.0375 mg, 0.075 mg, 0.15 mg, 0.3 mg, and 0.6 mg daily for 90 days with the probe, respectively. Damage to the tubular and glomerular structures was observed through microscopic examination of the preparations stained with hematoxylin-eosin. Results: The results of the One-Way ANOVA test showed a significant difference between groups with tubular damage (p <0.05). Meanwhile, the results of the Kruskal-Wallis test showed a significant difference between groups with glomerular damage (p <0.05). Conclusions: Multiple comparations indicated that exposure to microplastic started at 0.0375 mg daily had led to damage to the tubular and glomerular. Ingestion of microplastic particles causes renal tubular and glomerular damage in Wistar rats.

Item Type:	Article
Uncontrolled Keywords:	Glomerular Damage, Low-Density Polyethylene, Microplastics, Renal Tubular Damage, Wistar Rats
Subjects:	Medicine
Divisions:	Journal Publication
Depositing User:	F.X. Hadi
Date Deposited:	05 Apr 2024 06:43
Last Modified:	05 Apr 2024 06:43
URI:	http://repository.ukwms.ac.id/id/eprint/39532

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