Low-Density Polyethylene Microplastics in Blood Does Not Increase Serum Aβ1-42 Levels as a Biomarker of Alzheimer’s Disease in Wistar rats

Sincihu, Yudhiakuari, Elias, Saliza Mohd and Keman, Soedjajadi (2022) Low-Density Polyethylene Microplastics in Blood Does Not Increase Serum Aβ1-42 Levels as a Biomarker of Alzheimer’s Disease in Wistar rats. Low-Density Polyethylene Microplastics in Blood Does Not Increase Serum Aβ1-42 Levels as a Biomarker of Alzheimer’s Disease in Wistar rats, 13 (4). pp. 1827-1841. ISSN eISSN: 2229-7723; pISSN: 0976-9234

	Text (Low-Density Polyethylene Microplastics in Blood Does Not Increase Serum Aβ1-42 Levels as a Biomarker of Alzheimer’s Disease in Wistar rats) 6-Low-density_polyethylene_.pdf Download (575kB)
	Text (Low-Density Polyethylene Microplastics in Blood Does Not Increase Serum Aβ1-42 Levels as a Biomarker of Alzheimer’s Disease in Wistar rats) 6-Low-density_polyethylene_hasil cek similarity.pdf Download (1MB)

Official URL: https://www.pnrjournal.com/index.php/home/about

Abstract

The presence of microplastics in the blood circulation will trigger the formation of free radicals as a cause of damage to brain neurons. The large number of dead neuron causes a decrease in cognitive function which is the pathological of Alzheimer's disease. Amyloid beta 1-42 (Aβ1-42) levels in blood serum was a biomarker of Alzheimer's disease. This study aim was to explain the effect of microplastic particles in the blood toward the accumulation of Aβ1-42 levels in blood serum. Materials and methods: This study was a purely experimental study with post-test group design by using 42 Wistar rats which were divided equally into six groups. The control group was no exposed to microplastics, study group 1 (X1) was given 0.0375 mg/days, 2 (X2) was given 0.075 mg/day, 3 (X3) was given 0.15 mg/day, 4 (X4) was given 0.3 mg/day, and 5 (X5) was given 0.6 mg/day. Microplastics dry powder <20 μm in size mixed with 2 cc of distilled water and given through a probe for 90 days. Result: Microplastic particles have been found in the blood of Wistar rats, which were in higher number along with the group exposed to high doses of microplastics. There was an increase in Aβ1-42 levels in blood serum in the study group exposed to small doses, whereas decreased in the study group exposed to larger doses. Statistical analysis between two variables using by Spearmen’s rho test showed p value >0.05. Conclusions: There was no evidence that microplastic particles in the blood lead to increase Aβ1-42 levels in blood serum to assess cognitive abilities in Alzheimer's disease. It is concluded that microplastic particles in the blood does not induce Alzheimer's disease in Wistar rats.

Item Type:	Article
Uncontrolled Keywords:	Alzheimer's disease, amyloid beta 1-42, environmental pollution, microplastics, Wistar rats.
Subjects:	Medicine
Divisions:	Journal Publication
Depositing User:	F.X. Hadi
Date Deposited:	05 Apr 2024 01:46
Last Modified:	05 Apr 2024 01:46
URI:	http://repository.ukwms.ac.id/id/eprint/39526

Actions (login required)

View Item