Utilization of APTES-functionalized coconut waste-based cellulose microfiber/zeolitic-imidazolate framework-8 composite for curcumin delivery

Wijanarko, Marvel Guntur, Widagdo, Antonius Jimmy, Ismadji, M.S., Kusuma, K., Yuliana, Maria, Ismadji, Suryadi, Hartono, Sandy Budi, Lie, Jenni, Shu, H., Abdullah, Hairus, Kadja, G.T.M., Wijaya, C.J. and Soetaredjo, Felycia Edi (2023) Utilization of APTES-functionalized coconut waste-based cellulose microfiber/zeolitic-imidazolate framework-8 composite for curcumin delivery. Utilization of APTES-functionalized coconut waste-based cellulose microfiber/zeolitic-imidazolate framework-8 composite for curcumin delivery, 21. p. 100332. ISSN 2589-2347

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Abstract

With more than 7 million tons of coconut husk generated annually, this study proposes to fabricate the composite of coconut waste-based cellulose microfibers and zeolitic imidazolate framework-8 functionalized with (3-aminopropyl)-triethoxysilane (APTES-CMF/ZIF-8), which is used for curcumin uptake/release. The surface area and pore volume of APTES-CMF/ZIF-8 are found, respectively, at 247.6 m2/g and 0.21 m3/g. The morphology study also shows that the waste-based CMF possesses a uniform width at 5 e10 mm, and a length of up to several tens of microns, while the impregnated ZIF-8 has a rhombic dodecahedron shape with a particle diameter of 300e400 nm. The behavior of the curcumin uptake using APTES-CMF/ZIF-8 is elucidated via kinetics, isotherm, and thermodynamic studies. The maximum curcumin adsorption reaches 626.4 mg/g at the following condition: APTES-CMF/ZIF-8 loading (mc) ¼ 0.1% (w/w), uptake duration (t) ¼ 1440 min, temperature (T) ¼ 30 �C, and initial curcumin concentration of 1000 mg/L. This uptake follows the pseudo-second-order law and monolayer mechanism, with the fast migration of curcumin from the bulk solution to the surface of APTES-CMF/ZIF-8 as the rate-governing step. The curcumin and APTES-CMF/ZIF-8 interaction is driven by the electron exchange between both molecules. The release study of curcumin from Cur@APTES-CMF/ZIF-8 complies with the slow-first-order model. Moreover, the cumulative release is monitored at 74.2% at pH 5.5 and 47.9% at pH 7.4, signifying the pH-responsiveness of APTES-CMF/ZIF-8.

Item Type: Article
Uncontrolled Keywords: Coconut waste Cellulose microfibers Zeolitic-imidazolate framework-8 Composite material Drug delivery system Curcumin
Subjects: Engineering > Chemical Engineering
Divisions: Journal Publication
Depositing User: F.X. Hadi
Date Deposited: 17 Nov 2023 06:14
Last Modified: 02 Feb 2024 05:42
URI: http://repository.ukwms.ac.id/id/eprint/37379

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