Enhancing immunomodulatory of Javanese turmeric (curcuma xanthorriza) kombucha against diethylnitrosamine in male Balb/c mice

Zubaidah, Elok, Dea, Eirene Charista, Rahayu, Aldilla Putri, Fibrianto, Kiki, Saparianti, Ella, Sujuti, Hidayat, Godelive, Laura, Srianta, Ignatius and Tewfik, Ihab Enhancing immunomodulatory of Javanese turmeric (curcuma xanthorriza) kombucha against diethylnitrosamine in male Balb/c mice. Process Biochemistry, 133. pp. 303-308. ISSN 1873-3298

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Abstract

Kombucha is a fermented tea beverage, made by the addition of symbiotic culture of bacteria and yeasts (SCOBY). This study utilized Javanese turmeric in a concentration of 0.4 % (w/v) as a kombucha fermentation medium and evaluated its immunomodulatory activity, compared to non-fermented Javanese turmeric beverage. Forty-two healthy male BalB/C mice (20–30 g, 2–3 weeks old) were divided randomly into five groups with seven mice each. The groups were fed: Normal diet; normal diet + Javanese turmeric kombucha; normal diet + diethylnitrosamine (DEN); DEN + non-fermented Javanese turmeric and DEN + Javanese turmeric kombucha. Kombuchas and non-fermented Javanese turmeric were given at dose of 0.3 mL/20 g BW/day. The mice were injected with 100 mg/kg DEN intraperitoneally. The spleen was collected and analyzed for CD4+, tumor necrosis factor α (TNF-α+), interleukin-6 (IL-6+), CD8+, CD11b+, and IL-10+. The statistical analyses included ANOVA and the Fischer’s exact test. The percentage of CD8+, CD11b+, and CD8+ IL-10+ increased significantly (p < 0.05) among DEN-induced groups, Javanese turmeric kombucha and these values were higher than nonfermented Javanese turmeric. These findings verify that Javanese turmeric kombucha possessed better immunomodulatory activity compared to non-fermented Javanese turmeric.

Item Type:	Article
Subjects:	Agriculture and Food Technology
Divisions:	Journal Publication
Depositing User:	Ignatius Srianta
Date Deposited:	29 Oct 2023 03:13
Last Modified:	02 Nov 2023 07:25
URI:	http://repository.ukwms.ac.id/id/eprint/37148

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