Optimization of Coating Formula of White Pomegranate Peel Extract (Punica granatum L.) Film Coated Tablet Using Kollicoat Protect

Luke, Stefany, Ervina, Martha and Hadisoewignyo, Lannie (2021) Optimization of Coating Formula of White Pomegranate Peel Extract (Punica granatum L.) Film Coated Tablet Using Kollicoat Protect. Optimization of Coating Formula of White Pomegranate Peel Extract (Punica granatum L.) Film Coated Tablet Using Kollicoat Protect, 1 (1). pp. 19-29. ISSN 2776-5075

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Abstract

White pomegranate peel has many kinds of uses, one of them as antimalaria. The unpleasant appearance and bitter taste of white pomegranate peel tablets can be covered by film coated using Kollicoat Protect. This research aimed to determine the effect of concentration and type of solvent used as a coating on the physical properties of the coated tablets and determine the optimum formula. Tablets were made using the direct compression method and then coated using Kollicoat Protect. The optimization of the coating formula was performed using a factorial design with design expert software ver 10.0. Responses used were tablet hardness, friability, disintegration time, and increasing tablet mass. The results of this study showed that Kollicoat Protect cause increase of weight gain tablets and decrease the tablet friability, but prolong the disintegration time of tablets and decrease the tablet hardness while the type of solvent can increase of weight gain tablets, tablet hardness, and decrease the tablet friability but prolong the disintegration time of tablets. The optimum combination formula was Kollicoat Protect at 13.6% and a combination of water: alcohol (1:0.863) (w/v) with a theoretical response to the weight gain of 2.340%; hardness 7.950 KP; friability 0.022%; and disintegration time 20.938 minutes.

Item Type:	Article
Uncontrolled Keywords:	Punica granatum, tablet salut film, air, alkohol, Kollicoat Protect
Subjects:	Pharmacy
Divisions:	Journal Publication
Depositing User:	F.X. Hadi
Date Deposited:	27 Feb 2023 08:51
Last Modified:	21 Mar 2023 05:46
URI:	http://repository.ukwms.ac.id/id/eprint/34377

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