The effect of surfactants modification on nanocrystalline cellulose for paclitaxel loading and release study

Putro, Jindrayani Nyoo, Ismadji, Suryadi, Gunarto, Chintya, Yuliana, Maria, Santoso, Shella Permatasari, Soetaredjo, Felycia Edi and Ju, Yi-Hsu (2019) The effect of surfactants modification on nanocrystalline cellulose for paclitaxel loading and release study. The effect of surfactants modification on nanocrystalline cellulose for paclitaxel loading and release study, 282 (15). pp. 407-414. ISSN 01677322, 18733166

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Abstract

The Nanocrystalline cellulose (NCC) was prepared fromfilter paper by acid hydrolysis process. The modification of NCCwith cationic, anionic, and nonionic surfactant did not have a tremendous effect on the chemical structure ofmaterial based on the characterization of XRD and FTIR. Themodified NCCswere employed as a drug carrier for paclitaxel (PTX). Increasing concentration of ionic surfactants can enhance the loading of the hydrophobic drug, while the opposite trend was observed for nonionic surfactant modified nanocrystals. The attachment of surfactant toward the particle was a more likely physical aggregation of micelle on the surface of nanocrystals. Larger particle size was observed after the modification of nanocrystal cellulose. The fitting of Higuchi and sigmoidal models were applied in the release profile to investigate the kinetic release mechanism of paclitaxel at pH 5.8 and 7.4. Cell viability was determined to check the biocompatibility of the materials toward mouse osteoblast cells 7F2 usingMTT assay. Toxic behavior was not observed for NCC, while CTAB was completely not compatible with cells.

Item Type:	Article
Additional Information:	Jurnal Internasional Bereputasi SJR(2020): 0.93, Q1, H-Index: 111
Uncontrolled Keywords:	Nanocrystalline cellulose Surfactant Paclitaxel Drug delivery
Subjects:	Engineering > Chemical Engineering
Divisions:	Journal Publication
Depositing User:	F.X. Hadi
Date Deposited:	30 Jun 2022 07:10
Last Modified:	02 Aug 2022 05:08
URI:	http://repository.ukwms.ac.id/id/eprint/30793

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