Synthesis, characterization, and optimization of biodegradable pcl-peg-pcltriblock copolimeric micelles as nanocarriers for hydrophobic drug solubility enhancer

Prasetyo, Jefri, Sulaiman, Teuku Nanda Saifullah and Lukitaningsih, Endang (2020) Synthesis, characterization, and optimization of biodegradable pcl-peg-pcltriblock copolimeric micelles as nanocarriers for hydrophobic drug solubility enhancer. Synthesis, characterization, and optimization of biodegradable pcl-peg-pcltriblock copolimeric micelles as nanocarriers for hydrophobic drug solubility enhancer, 12 (2). pp. 5-10. ISSN 0975-7066, Jurnal Internasional SJR(2020) 0, Q4, H-Index 4

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Abstract

Objective: This study aims to synthesize, characterize, and optimize biodegradable polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) triblock copolimeric micelles as a nanocarrier for hydrophobic drug solubility enhancer of ketoprofen (K). Methods: PCL-PEG-PCL (PCEC) triblock copolymers was obtained from the synthesis of ɛ-caprolactone (ɛ-CL) and PEG by ring opening polymerization (ROP) method at different PCL: PEG ratio (2-5:1). The K-loaded PCEC triblock copolymeric micelles was obtained by solvent evaporation method. Optimization of PCEC triblock copolymers and analysis of the effect of PCL: PEG ratio factors on the responses toward particle size (PS), polydispersity index (PdI), and entrapment efficiency (EE), were carried out through the design of experiments (DoE) approach of the 22 Results: The higher the PCL: PEG ratio, the ZP value tends to be smaller while the PS, PdI, EE, and drug solubility may be increased, but the addition of hydrophobic blocks to some extent does not affect the EE and drug solubility. The optimum K-loaded PCEC triblock copolymeric micelles with a PCL: PEG 2.0:1 ratio has a zeta potential (ZP) of-24.07±0.35 mV, the particle size of 235.70±6.03 nm, polydispersity index of 0.30±0.06, entrapment efficiency of 87.08±0.06%, and the solubility of the K increases by 10.60 times. full factorial design method using the Design-Expert software to obtain the optimum formula. Conclusion: The 22

Item Type:	Article
Additional Information:	Jurnal Internasional SJR(2020) 0, Q4, H-Index 4
Uncontrolled Keywords:	Optimization, Triblock copolymers, PCL, PEG, Ketoprofen
Subjects:	Pharmacy
Divisions:	Journal Publication
Depositing User:	F.X. Hadi
Date Deposited:	17 Jan 2022 06:59
Last Modified:	17 Jan 2022 06:59
URI:	http://repository.ukwms.ac.id/id/eprint/28666

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