Hadisoewignyo, Lannie and Pujianto, Ellisabet (2010) Optimasi Tablet Ibuprofen Menggunakan Simple Lattice Design. Optimasi Tablet Ibuprofen Menggunakan Simple Lattice Design, 5 (2). pp. 631-640. ISSN 1987-8495
Preview |
Text (Optimasi Tablet Ibuprofen Menggunakan Simple Lattice Design)
03- Optimasi_tablet_ibuprofen_.pdf Download (6MB) | Preview |
Preview |
Text (Optimasi Tablet Ibuprofen Menggunakan Simple Lattice Design)
03- Optimasi_tablet_ibuprofen_Hasil Cek Similarity.pdf Download (6MB) | Preview |
![[thumbnail of Optimasi Tablet Ibuprofen Menggunakan Simple Lattice Design_peer_review_]](http://repository.ukwms.ac.id/style/images/fileicons/text.png) |
Text (Optimasi Tablet Ibuprofen Menggunakan Simple Lattice Design_peer_review_)
13- R1&2-Optimasi_tablet_ibuprofen_.pdf Download (1MB) |
Abstract
The aim of this research is to obtain the oplimum mixture proportions of Vivapur® Type 101 (microcrystalline cellulose) and lactose monohydrate on ibuprofen tablets made by wet granulation method. Vivapur® type 101 and lactose monohydrate when combined may have a synergistic effect that can improve the physical properties of tablets influencing effect on the quality of tablets. Optimization design used in this study was the simplex lattice design, using Design Expert® program. Responses used in determining the optimum formula were tablet hardness, tablet friability, disintegration time of tablets, and the percent of drug released within 30 minutes. The results showed that the polynomial equation for hardness was Y = 6.9633 XA + 4.5567 XB + 6.1868 XAB; friability was Y = 0.4956 XA + 0.6071 XB - 0.2198 XAB; tablet disintegration time was Y = 1 XA + 17.337 Xn + 14.02 XAB; and percent of drug released within 30 minutes was Y = 96.38 XA + 79.49 Xn - 23.50 XAB· Concluded that Vivapur® type 101 and lactose monohydrate was the dominant affecting factor on tablet hardness, tablet friability, disintegration time of tablets, and the percent of drug released within 30 minutes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ibuprofen, Vivapur, lactose monohydrate, simplex lattice design. |
| Subjects: | Pharmacy |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 24 May 2021 07:44 |
| Last Modified: | 07 Feb 2022 07:54 |
| URI: | http://repository.ukwms.ac.id/id/eprint/25606 |
Actions (login required)
 |
View Item |