Amine functionalized cubic mesoporous silica nanoparticles as an oral delivery system for curcumin bioavailability enhancement

Hartono, Sandy Budi, Hadisoewignyo, Lannie, Yang, Yanan, Meka, Anand Kumar, Antaresti, - and Yu, Chengzhong (2016) Amine functionalized cubic mesoporous silica nanoparticles as an oral delivery system for curcumin bioavailability enhancement. Journal Nanotechnology, 27 (50). pp. 1-7. ISSN ISSN: 09574484, ISSN: 13616528, Journal Internasional Bereputasi Q1 (2016), SJR 1,339

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Abstract

In the present work, a simple method was used to develop composite curcumin-amine functionalized mesoporous silica nanoparticles (MSN). The nanoparticles were used to improve the bioavailability of curcumin in mice through oral administration. We investigated the effect of particle size on the release profile, solubility and oral bioavailability of curcumin in mice, including amine functionalized mesoporous silica micron-sized-particles (MSM) and MSN (100–200 nm). Curcumin loaded within amine functionalized MSN (MSN-A-Cur) had a better release profile and a higher solubility compared to amine MSM (MSM-A-Cur). The bioavailability of MSN-A-Cur and MSM-A-Cur was considerably higher than that of ‘free curcumin’. These results indicate promising features of amine functionalized MSN as a carrier to deliver low solubility drugs with improved bioavailability via the oral route.

Item Type:	Article
Uncontrolled Keywords:	mesoporous silica nanoparticles, oral delivery platform, curcumin
Subjects:	Pharmacy
Divisions:	Journal Publication
Depositing User:	F.X. Hadi
Date Deposited:	19 Jan 2021 06:34
Last Modified:	08 May 2023 08:34
URI:	http://repository.ukwms.ac.id/id/eprint/24096

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